Rapid tests for hepatitis b

Appropriate use

Simple and rapid tests for the detection of HBsAg can be used in rural clinics, hospitals, or blood banks in settings where laboratory-based tests are not appropriate. Accurate results allow for same-day patient follow-up. In the case of blood banks or transfusion centers, very rapid results are needed, especially in emergencies or in situations requiring replacement donations. Intermediate- to peripheral-level clinics, hospitals, and central blood banking facilities can use rapid hepatitis B tests as a back up to standard enzyme immunoassay (EIA) testing. Secondary applications include case-finding and epidemiological surveillance.

Links to more information

• Tests for acute and chronic viral hepatitis
  This online course includes information on which serologic tests are most helpful for diagnosis of chronic hepatitis B infection.
• Merck Manual Chapter on Acute Viral Hepatitis
  This chapter of the Merck Manual  provides clinicians with tips on differential diagnosis of acute hepatitis and other disease that may cause jaundice or similar symptoms as a viral hepatitis. It also provides basic information on nonspecific liver function tests, including aminotransferases, bilirubin, and alkaline phosphatase.
• Hepatitis B Surface Antigen Assays: Operational Characteristics
  This link presents the findings of the Phase I evaluations of 10 HBsAg assays conducted by WHO during September to November 1999, and January to May 2001.
• Hepatitis B Surface Antigen Assays: Operational Characteristics (Report 2)
  This second link presents the findings of the Phase I evaluations of 5 HBsAg assays conducted between September 2001 and January 2004.